Metalyse: see the main information of the package insert and the price

Pain in the chest, arms and jaw, heartburn , indigestion, dizziness and cold sweat. These are some of the symptoms that occur in people who are suffering from a heart attack.

Also called a heart attack, heart attack is considered a critical problem that needs emergency care.

For your treatment, there are medications like Metalyse.

Learn more about the medicine and how to use it:


What is Metalyse?

Metalyse is a drug applied intravenously (in the vein), used to treat cases of heart attack.

Its active ingredient is Tenecteplase, a thrombolytic drug – a medicine that dissolves blood clots that interrupt the flow of blood.

This way, when using the medication, the normal blood flow to the heart is restored.

What is Metalyse for?

According to the package leaflet, Metalyse is a drug that has an indication for adult use and is used to treat clots in cases of infarction.

It works by stimulating the dissolution of these blood clots, which are blocking the correct flow of blood to the heart.

What is the dosage indicated on the label?

Metalyse has two presentations: 40mg or 50mg. According to the package insert, the amounts of administration must be carried out according to the patient’s weight.

The table below refers to the reconstituted, that is, prepared dosage. Each mL of the reconstituted dose contains 5mg of the active substance:

Weight (kg)Reconstituted dose (mL)
Under 60kg6mL
Between 60kg and 70kg7mL
Between 70kg and 80kg8mL
Between 80kg and 90kg9mL
Over 90kg10mL

Despite the indications, it is important to always follow medical advice, with the dose and times recommended by the professional.

Metalyse how to administer each dose?

The route of administration of Metalyse is intravenous (in the vein) and its application must be carried out under the supervision of a qualified professional. For preparation, it is necessary to make the dilution, which must follow the recommended procedures. Therefore, only professionals should do it.

It should be done quickly, for an approximate time of 5 to 10 seconds.

The maximum recommended dose is 50mg of the active substance, which, according to the package insert, is equivalent to 10,000 units of the drug.

What side effects are on the label?

Like other medicines, the use of Metalyse can result in some side effects.

According to the package leaflet, the main ones are related to bleeding.

Common reactions include:

  • Vomiting with blood;
  • Diarrhea with blood;
  • Bleeding from the nose;
  • Purple spots on the skin;
  • Bleeding in the mouth;
  • Hemorrhages in the digestive system;
  • Hemorrhage at the injection site;
  • Hemorrhage in Organs genitals;
  • Blood in the urine.

The least common, but with a chance of happening, are:

  • Bleeding in the brain;
  • Leakage;
  • Hemorrhage in the eye;
  • Change in heart rate.

Among the rare effects are:

  • Hemorrhage around the heart;
  • Hemorrhage in the lung;
  • Allergic reaction;
  • Drop in blood pressure;
  • Blood flow interrupted due to a blood clot.

It is worth remembering that despite the items listed, each organism reacts differently to the medication. In this way, not all patients will necessarily suffer all side effects.

What is the price of Metalyse 50mg?

Metalyse is a high-priced drug, which varies according to its dosage.

It has two presentations: Metalyse 40mg and Metalyse 50mg.

The Metalyse 40mg costs, on average, US $ 6800 *.

Already 50mg Metalyse, costs around R $ 8400 *.

* Prices consulted in December 2019. Prices may vary.

However, patients with a medical indication for the use of the drug can go to court to receive it.

For this, it is necessary to open a case, following the stipulated procedures. Among them, submit the Medical Report, exams, standard requirement, in addition to the budget of 3 pharmacies.

For those who will make the request, it is possible to count on the assistance of a high cost medication quotation advisory , which realizes a personalized budget, in a simple and facilitated way.

Does Metalyse have generic?

No . A generic drug for Metalyse has not yet been registered. Thus, the only option currently available is Metalyse.

Does ANVISA approve Metalyse?

-Yeah . The product was approved by Anvisa in 2001, with therapeutic class of fibrinolytics and proteolytics – drugs that dissolve blood clots and proteins .

It is classified as a new drug and was the first drug produced using the active ingredient Tenecteplase.

Metalyse and Actilyse

Metalyse and Actilyse are both thrombolytic drugs, those indicated to dissolve blood clots in cases of myocardial infarction.

Both drugs are applied intravenously (into the vein) and have a similar action in the treatment of heart attack.

However, the Actilyse package insert also indicates that the drug can be used to treat cases of acute ischemic stroke and acute pulmonary embolism – pulmonary artery blockage due to a clot.

The choice of which drug to use must be made by the responsible physician, who will evaluate the best option for each clinical picture.

Both are expensive drugs and must be administered by a trained health professional.

Heart attacks are more common than you think. Only in Brazil there are about 150 thousand cases per year.