Losartana: is it for high blood pressure? How to take according to the package insert?

About 25% of the Brazilian population suffers from high blood pressure , a condition that causes the heart to work harder and is a risk factor for stroke, heart attack , etc.

This is a pathology that has no cure and can have different causes: genetic factors, obesity , excessive use of alcohol or tobacco, diabetes , stress , etc.

When a person suffers from hypertension (high blood pressure), it is common that they need to take medication to treat the problem for the rest of their lives. Among these, is the remedy Losartana.

See, below, how this medication works in the body and information about its use:


What is Losartana?

Losartan potassium is a medicinal substance, present as an active ingredient (AP) in remedies indicated for the treatment of hypertension (high blood pressure), a chronic disease that can often manifest symptoms.

In general, people with blood pressure higher than 140 x 90 mmHg (millimeter per mercury) are classified as hypertensive – or 14 by 9. Highlighting that the condition is more recurrent in people over 60, who smoke, who consume too much salt or are sedentary, for example.

Despite being a problem that can be treated and controlled, hypertension has no cure and needs medical monitoring – especially because it is a risk factor for problems such as stroke, kidney failure and heart attack.

In this sense, Losartana acts by controlling the change in pressure and can be used alone or in conjunction with a diuretic medication (such as Hydrochlorothiazide).

In addition to treating hypertension, it can also be indicated for the treatment of heart failure, renal protection in patients with type 2 diabetes and cases of proteinuria (elimination of protein in the urine due to renal complication).

It is also used to reduce the risk of cardiovascular morbidity and mortality in hypertensive patients with left ventricular hypertrophy – an increase in the thickness of the heart’s ventricles.

Also, Losartana is available for oral administration, in 25mg, 50mg and 100mg tablets, so that the dosage varies according to each patient, but it is always administered once a day.

This is because it controls blood pressure for 24 hours, not inducing hypotension (drop in pressure) in the first hours. This allows for single administration.

Finally, it is worth noting that it is not recommended for pregnant women, nursing mothers or people with diseases of the liver, kidneys or heart failure.

What is the medicine Losartana for?

According to the package insert, Losartana’s main indication is for the treatment of people with high blood pressure problems ( hypertension ). In such cases, continuous use is almost always necessary as a form of maintenance, since the condition has no cure.

In addition, Losartana can also help reduce the risk of cardiovascular disease (such as stroke and myocardial infarction).

In this sense, medication helps to reduce the risk of cardiovascular morbidity and mortality. The package insert indicates that this assessment was made based on the incidence of cardiovascular death, stroke and infarction in hypertensive patients with left ventricular hypertrophy.

In addition, it can slow the progression of kidney disease and reduce proteinuria – elimination of protein in the urine caused by impaired kidneys.

When indicated for these situations, the goal is that Losartana can slow the progression of kidney disease (even in patients with end-stage renal failure). In addition to also decreasing proteinuria.

However, its main prescription is still as an antihypertensive medication .

What is the effect of losartan?

Losartan is categorized as an angiotensin II receptor antagonist (determinant of the pathophysiology of hypertension). In this sense, the medication works by dilating blood vessels to facilitate the pumping of blood from the heart to the rest of the body.

That’s because angiotensin II normally narrows blood vessels. Then, the treatment with Losartana acts for the vessels to relax.

With this, it helps to reduce high blood pressure and, in patients with heart failure, assists in the better functioning of the heart. In addition, because of its action, it also decreases the risk of heart disease and blood vessels (such as stroke) in patients with high blood pressure and left ventricular hypertrophy.

According to the directions on the label, this medication can also help protect the kidneys in cases of type 2 diabetes and proteinuria (loss of protein in the urine due to impaired kidneys).

Does Losartan Potassium have a diuretic effect? Do you lose weight?

Although Losartana works by lowering blood pressure, as well as diuretic drugs, it does not increase the elimination of fluids. That is, it has no diuretic effect .

However, experts often indicate the use of a diuretic medication with Losartana, such as Hydrochlorothiazide . What is done in order to enhance the antihypertensive effects.

Anyway, the use of medication does not lose weight (with or without a diuretic). This is because even substances that aid the functioning of the urinary system do not provide weight loss.

Whereas, in these cases, what happens is only the greatest elimination of fluids and not of body fat. So, even if the person feels the swelling decrease, it does not correspond to a real weight loss.

It is worth mentioning, however, that in some isolated cases the use of Losartana can cause a feeling of bloating as a side effect.

What milligram is available?

The drugs that rely on Losartana as an active ingredient are available in milligrams of 25mg , 50mg and 100mg . All in compressed version.

In general, this facilitates when administering the dose, considering that the maximum dose mentioned on the package insert is 100mg daily – when there are indications that it may bring additional benefit to the patient.

In addition, since the dose may also be lower (such as 25mg), it also helps so that the person does not need to break the pill.

Remember to follow the medical advice when buying the medicine, check if the medication corresponds to what was prescribed.

Dosage: how to use according to the package leaflet?

According to the package insert, usually the indicated dose of Losartana for initiating and maintaining treatment is 50 mg given once a day.

In some specific cases, the doctor may increase the dose to 100mg once a day. This, only when proven that there may be some additional benefit.

It is worth noting that for patients treated with high doses of diuretics (or with loss of extracellular fluid volume), a dose of only 25mg daily should be considered.

Remembering that this must be decided by responsible professionals, based on each case.

The package insert also reinforces that there is no need to adjust the dosage for the elderly or patients with renal dysfunction (even if on dialysis). But for those who have a history of liver problems, a lower dose is recommended.

How many losartan can I take per day?

The amount of pills taken each day depends on how many milligrams were prescribed in the prescription. That is, remember to always check the indicated dosage and check the milligrams in the box, as there are versions with 25mg, 50mg and 100mg.

As mentioned, the package insert indicates that the maximum dose is restricted to 100mg per day. But the indication is usually 50mg daily (in a single dose) in most cases. In specific cases, when the dose is less than or greater than 50mg, administration is also done in one go.

It is worth mentioning that it is essential to follow the medical recommendation regarding the use of the medication, in order to make it safe to use and present the desired results.

In addition, there may be specific situations in which the daily amount of pills may be higher or lower than indicated. Provided that according to professional guidance.

But, in general, it is important to always follow the instructions of the package insert:

  • Heart failure patients – the initial dose is usually 12.5mg per day, going through 25mg, until the usual maintenance dose (50mg daily) is reached;
  • Patients with type 2 diabetes or proteinuria (for kidney protection ) – the usual dose is 50mg, which can reach up to 100mg daily in specific cases.

How long does losartan take to take effect?

In general, in the first hours after ingesting Losartana, it already begins to have an effect on the body. However, the package insert indicates that its maximum antihypertensive effect should occur 3 to 6 weeks after the start of therapy.

Therefore, it is common for the person to begin to feel the effects during this period. When this does not happen, the ideal is to seek help from the doctor responsible for the treatment.

This way, he / she will be able to make a diagnosis and evaluate the need for dose changes and / or medication. Still, it is also possible that you choose to wait another period before making changes to the treatment.

All this considering that, almost always, Losartana is a medication of continuous and prolonged use – so that greater results are notorious in the long term.

What are the side effects of Losartana?

Like any medication, Losartana can also cause side effects in those who use it. However, the package insert indicates that in general they are mild reactions and that it is usually not necessary to interrupt the treatment.

The possible adverse reactions, listed on the product leaflet, are:

  • Hypersensitivity;
  • Swelling of the face, lips and / or tongue;
  • Dizziness;
  • Fatigue;
  • Rash;
  • Malaise;
  • Weakness;
  • Abdominal pain;
  • Swelling;
  • Chest pain;
  • Nausea;
  • Pharyngitis;
  • Diarrhea;
  • Headache;
  • Insomnia;
  • Cramps;
  • Nasal congestion.

Read more: What are the symptoms and treatments for Pharyngitis?

It is worth noting that the package insert indicates different frequencies of adverse effects according to each case. So, if there are any symptoms, seek medical or pharmaceutical advice.

In case of the manifestation of one (or more) side effects, seek medical assistance in order to diagnose whether the problem is related to the use of medication. In any case, the doctor will be able to indicate the correct care.

Chest pain (left and right): causes and what can be

Does Losartana make you sleepy?

-Yeah . In some cases, the use of Losartana can cause side reactions involving sleep disorders – both in the sense of causing drowsiness and causing insomnia .

That way, even if the package insert indicates that in general the side effects of this medication are mild, you can feel some of these changes.

Considering that Losartana in general is of continuous use, if you feel any changes, seek medical assistance. Thus, the professional will be able to diagnose if the problem is (or not) associated with the medication.

If so, it will be possible to indicate treatments or care that can help to decrease and even eliminate these unwanted reactions.

Contraindication: who cannot take losartan?

According to the package leaflet, Losartan is contraindicated for people with hypersensitivity to losartan potassium (active ingredient) or to another component of the formula. Still, it should not be used by people with diseases of the liver, kidneys or heart failure, in addition to pregnant women (from 3 months) or breastfeeding.

Therefore, it is essential that the cardiologist responsible for your case has access to all this information in advance.

In addition, the concomitant use of Losartana with products containing aliskiren is not indicated for patients with diabetes mellitus and renal failure.

It is of utmost importance that you follow the instructions regarding the administration of this medication correctly in order to make it safe to use.

Price: what is the average value of Losartana?

Losartana is the active ingredient in several medications, classified into different versions (reference, generic and similar) – which can cause variation in values.

In this sense, check below some of the medications based on Losartana and their respective prices *:

  • Losartana Potássica EMS (generic) – the box with 30 tablets of 50mg varies between R $ 6 and R $ 15;
  • Corus (similar interchangeable) – available in boxes of 25mg and 50mg, varying between R $ 5 and R $ 35;
  • Losartec (reference) – the price of the box (25mg and 50mg) can vary between R $ 25 and R $ 60;
  • Losartana Potássica Medley (generic) – available in boxes of 50mg and 100mg, varies between R $ 4 and R $ 30.

* Prices consulted in June 2020. Prices may change.

Remember to always follow the medical advice regarding the milligram and version of the medication, in order to carry out the treatment in a safe and appropriate way for your case.

What happens if I take too much Losartan?

According to the instructions on the package insert, in case of overdose it is essential to seek medical assistance immediately. In such cases, the symptoms that usually manifest are low blood pressure and fast heart rate .

However, in some cases, it is also possible for your heart rate to slow down.

Thus, the need to not exceed the dosage prescribed by the responsible physician is reinforced. Whereas, in addition to these symptoms, an overdose can also increase the risk of unwanted side effects.

Why take Losartan and Hydrochlorothiazide?

The use of Losartana is indicated for the treatment of people with high blood pressure. However, it is not uncommon to recommend joint use with Hydrochlorothiazide ( diuretic medication ). Thus, the combination of these remedies is made in order to potentiate the antihypertensive effects and decrease risks of cardiovascular events.

In this way, Losartana works by blocking angiotensin II (a substance that narrows blood vessels) and causes the vessels to relax. Hydrochlorothiazide, on the other hand, causes the kidneys to eliminate more salt and water.

This is necessary because not only do chemical substances (such as angiotensin) alter the pressure, but external factors such as excessive salt consumption can also cause this dysregulation.

Thus, the use of both medications tends to have greater effects under high blood pressure.

Treatment for hypertension (high blood pressure) is very important to maintain the quality of life of those who suffer from this condition. In addition to preventing more serious problems, such as stroke.

So, if this is your case, always carry out medical follow-up and follow the guidelines.

Keep following the Healthy Minute for more information on medicines, well-being and general health!

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