Ketoprofen: know the drug and how to use it correctly

Rheumatic diseases can provide great pain and discomfort for those who suffer from the problem. In addition to affecting the locomotor system, they can affect other organs of the body, interfering with their functioning.

For the relief and treatment of this type of problem, there are some medications that can be used, among them, Ketoprofen.

Keep reading and learn more about the medication!


What is Ketoprofen?

Ketoprofen is a non-steroidal anti-inflammatory substance (NSAID) – that is, of non-hormonal origin – used as an active ingredient in some medications.

It is indicated for the treatment of problems related to rheumatic processes, trauma, orthopedic injuries and pain in general. It can also be applied in some cases of otorhinolaryngological, urological, gynecological and dental problems.

It is available in tablet, capsule, rectal suppository , oral solution (drops), syrup, gel, solution for injection and lyophilic powder.

In general, it is indicated for adult use, with only syrup and oral solution versions also recommended for pediatric use (over 6 months and over 1 year, respectively).

What is the medicine for?

Ketoprofen is indicated for the relief of pain and inflammation caused by problems that affect different parts of the body, such as: rheumatic processes (diseases that affect muscles, joints and skeleton), traumatisms (internal or external injuries to the body) and body pain in general.

In some cases, ketoprofen can also be used to treat ENT, urological, gynecological and even dental problems.

In general, the indication may vary according to the presentation:

  • Rheumatic processes: capsule, tablet, rectal suppository, oral solution, solution for injection and lyophilic powder;
  • Trauma: capsule, tablet, rectal suppository, oral solution, solution for injection, lyophilic powder and gel;
  • Pains in general: capsule, tablet, rectal suppository, oral solution, solution for injection, lyophilic powder and gel;
  • Orthopedic injuries: capsule, tablet, oral solution, solution for injection and gel;
  • Pediatric fever and pain: syrup;
  • Otorhinolaryngological processes: oral solution;
  • Gynecological processes: oral solution;
  • Urological processes: oral solution;
  • Dental processes: oral solution.

Specifically, ketoprofen is indicated for cases of:

Rheumatic processes

Rheumatic processes are problems that affect muscles, joints and skeletons. Among the diseases that can be treated with Ketoprofen are:

  • Rheumatoid arthritis – inflammatory disease that affects the joints;
  • Ankylosing spondylitis – type of arthritis that affects the spine and large joints;
  • Gout – inflammation in the joints caused by the accumulation of uric acid in the blood;
  • Chondrocalcinosis – disease caused by the deposit of calcium pyrophosphate inside the joints;
  • Psoriatic rheumatism – type of arthritis that can affect people suffering from psoriasis skin disease;
  • Reiter’s syndrome – pain and swelling in the joints caused by inflammation in other parts of the body;
  • Pseudoarthritis – type of arthritis caused by the deposition of calcium pyrophosphate crystals in the joints;
  • Systemic lupus erythematosus – chronic inflammatory disease of autoimmune origin;
  • Scleroderma – chronic inflammatory disease that causes the connective tissues to stiffen;
  • Periarteritis nodosa – inflammation of medium-sized arteries;
  • Osteoarthritis – type of arthritis that causes cartilage wear;
  • Scapulohumeral periarthritis – limitation of shoulder movements and pain at the site;
  • Bursitis – inflammation of the bursae (fluid pouch that protects the joints);
  • Capsulitis – pain and stiffness in the shoulder joint;
  • Synovitis – inflammation of the tissue that internally surrounds the joints;
  • Tenosynovitis – inflammation of the tendon and the tissue covering it (sheath);
  • Tendonitis – inflammation of the tendon;
  • Epicondylitis – irritation of the tissue that connects the muscle of the forearm to the elbow.

Otorhinolaryngological processes

Some of the problems related to otorhinolaryngology, that is, that affect the nose, mouth and ears, which can be treated with ketoprofen are:

  • Sinusitis – inflammation of the mucous membranes of the face;
  • Otitis – inflammation of the ear;
  • Pharyngitis – inflammation of the pharynx;
  • Laryngitis – inflammation of the larynx;
  • Tonsillitis – inflammation of the tonsils.

Read more: What are the symptoms and treatments for pharyngitis?

Gynecological-obstetric processes

The gynecological-obstetric processes, that is, related to the female reproductive system, which can be treated with the drug are:

  • Anexitis – inflammation of the fallopian tubes;
  • Parametritis – inflammation of the tissue that surrounds the uterus;
  • Endometritis – inflammation of the endometrium;
  • Dysmenorrhea – cramps and pelvic pains before or during the menstrual period.

Urological processes

Among the urological processes, that is, that affect the male reproductive system, that the medication can be administered are:

  • Nephretic colic – pain caused by calculus in the urinary tract;
  • Orchiepididymitis – inflammation of the testicles and epididymis;
  • Prostatitis – swelling in the prostate.

Dental processes

Some problems related to the oral region can be treated with ketoprofen. Between them:

  • Periodontitis – infection of the gum;
  • Pulpitis – inflammation of the dental pulp (the deepest part of the teeth);
  • Abscesses – pouch of pus that accumulates in the tissues of the body;
  • Dental extractions .

Orthopedic injuries

For injuries to the locomotor system, ketoprofen can be administered in cases of:

  • Bruises and crushing ;
  • Fractures ;
  • Sprains – stretching or tearing of the ligaments;
  • Dislocations – dislocation of a joint.

General pains

Indications for general body aches include:

  • Cervicobraquial neuralgia – pain originating in the nerves of the neck, which radiates to the fingers;
  • Cervicalgia – pain in the neck and shoulder;
  • Low back pain – pain in the lower lumbar region;
  • Sciatica – inflammation or irritation of the nerve roots that lead to the sciatic nerve;
  • Migraine – headache that may be accompanied by nausea, sensitivity to light and blurred vision.
  • Several postoperative .

How does the ketoprofen active ingredient work?

Ketoprofen is a substance classified as non-steroidal anti-inflammatory drug (NSAID), that is, it does not have steroidal hormonal components in its composition. In general, it works by inhibiting the production of substances related to inflammation and pain.

Its mechanism of action is not yet completely known and what is known is that it prevents the synthesis of a hormone called Prostaglandin, which is related to the development of inflammation in the body. In doing so, there is relief from the inflammatory effects on the body.

The drug also acts to inhibit platelet aggregation – the mechanism of platelets joining one another – and has analgesic and antipyretic activity.

How long does it take Ketoprofen to take effect?

It depends . The duration of action of Ketoprofen varies according to the presentation of the medication. In general, the maximum absorption time, that is, the period that the drug takes to be absorbed by the body, for each version is:

  • Capsule – 60 to 90 minutes;
  • Tablet – 45 to 90 minutes;
  • Lyophilic powder – 5 minutes;
  • Solution for injection – 20 to 30 minutes;
  • Oral solution – 60 to 90 minutes;
  • Suppository – 45 to 60 minutes;
  • Syrup – 30 minutes.

Despite this, it is worth mentioning that, in general, the medication will start to act during this period, however, the improvement of symptoms depends on other factors, such as the intensity of the clinical picture and the organism’s response to the medication.

Dosage: how to use Ketoprofen 50mg and 150mg?

Each presentation of Ketoprofen has a different milligram and form of use. The 50mg version is the capsule version and the 150mg version is the extended-release tablet .

Specifically, the milligrams for each available presentation are:

  • Capsule: 50mg;
  • Delayed-release tablet: 100mg or 200mg;
  • Extended-release tablet: 150mg;
  • Rectal suppository: 100mg;
  • Oral solution: 20mg / mL;
  • Syrup: 1mg / mL;
  • Gel: 25mg / g;
  • Solution for injection: 50mg / mL;
  • Lyophilic powder: 100mg.

The dosage also changes according to the presentation indicated. For each variation, the mode of use is:


The capsule version is usually recommended to take 2 capsules, 2 times a day or 1 capsule, 3 times a day.

It is recommended to use the medicine during or after meals, together with a glass of water.

The maximum recommended daily dose is 300mg.


There are two main types of tablet versions of Ketoprofen: delayed-release and prolonged-release.

Delayed-release medications are those in which the medication is released into the body after a certain period of ingestion, not immediately after administration of the drug.

On the other hand, prolonged-release drugs are those in which the drug is released gradually into the body over a prolonged period of time.

The dosage indicated for each of them is:

Delayed release

The delayed-release tablets may generally have a milligram of 100mg or 200mg of ketoprofen.

In the case of the 100mg tablet , it is recommended to use:

  •  2 tablets daily, one in the morning and one in the evening.

However, if the milligram is 200mg , it is recommended to administer:

  •  1 tablet daily, morning or evening.

It is worth mentioning that, for this version, you should not exceed the amount of 1 tablet daily.

Prolonged release

In the case of the prolonged-release tablet, in general, there are two ways to administer the medication: one for the specific treatment of migraine and the other for general problems.

For use in the general case, the administration should be done in two steps: loading dose and maintenance dose .

The attack dose is one in which there is the objective of quickly reaching a certain concentration of the medication in the body, so that the body can tolerate the application of other doses later (which are the maintenance doses).

For general cases , the indication of use is commonly indicated is:

  • Attack dose: 2 tablets per day, divided into 2 applications;
  • Maintenance dose: 1 tablet, 1 time a day.

For the specific treatment of migraine , the recommendation is to take ½ tablet soon after the onset of the crisis.

It is worth mentioning that there must be an interval of at least 12 hours between the administration of one dose and another.

Thus, even if the symptoms are not relieved with the dose ingested, administration of a new dose is contraindicated before 12 hours of the last ingestion.

Rectal suppository

The rectal suppository is usually used for 1 application, 2 times a day (once in the morning and once in the evening).

To administer, some steps must be followed:

  1. Perform hand hygiene with soap and water;
  2. With your thumb and index finger, move your buttocks apart;
  3. Insert the suppository into the anal cavity;
  4. Gently press one buttock against the other, to prevent the medication from coming back.

On hot days, according to the package insert, it is recommended to put the medicine in cold water or refrigerator for a few minutes before removing it from the packaging, to prevent it from softening.

Oral solution (drops)

The oral solution, that is, in drops, must be diluted with a little water for administration.

The use for children is:

  • Above 1 year: 1 drop per kg of weight every 6 or 8 hours;
  • From 7 to 11 years: 25 drops, every 6 or 8 hours.

As for application in adults, the indicated is:

  • 50 drops every 6 or 8 hours.


Syrup is the pediatric version of Ketoprofen. For its administration, normally the indication is that the dosage must be:

  • 0.5mg / kg / dose, 3 to 4 times a day.

It is worth mentioning that it is necessary to have an interval of 4 hours between each application. In general, the treatment period varies between 2 to 5 days.


To administer the gel version, just apply the product under the inflamed site, 2 to 3 times a day, massaging for a few minutes.

The amount of product should cover the entire area of ​​the affected area, however, the daily dose should not be greater than 15g.

In addition, treatment with the drug should not exceed the period of 1 week.

Solution for injection

The injectable solution is applied intramuscularly, that is, inside the muscle. It must be administered by a health professional and the recommended dosage is 1 ampoule, 2 to 3 times a day.

The injection should be done in the upper quadrant of the buttock, slowly and deeply. Before applying, it is worth aspirating the syringe to confirm that the needle is not in a blood vessel.

Lyophilic powder

The administration of the lyophilic powder version is made exclusively intravenously, that is, directly into the vein, and must be applied by a trained health professional.

Before use, it is necessary to dissolve the lyophilic powder. The steps for preparation and application are:

  1. Dilute the contents of the flask in 100mL to 150mL of isotonic solution of glucose or sodium chloride, immediately before use;
  2. Administer via slow infusion for approximately 20 minutes.

For renal colic attacks, treatment should not exceed 48 hours.

What are the side effects according to the package leaflet?

Like other medications, ketoprofen can cause side effects in some people.

It is worth remembering that each organism reacts differently to the drug. Thus, not all patients will necessarily suffer from the reactions.

Among the common side effects caused by medication, considering all presentations, are:

  • Dyspepsia – indigestion;
  • Nausea;
  • Abdominal pain;
  • Vomiting.

Among the unusual reactions , which can occur, are:

  • Headache – headache;
  • Vertigo – dizziness;
  • Somnolence;
  • Constipation – constipation;
  • Diarrhea;
  • Flatulence – gases;
  • Gastritis;
  • Rash;
  • Itching – itching;
  • Edema – swelling.

Rare reactions are:

  • Weight gain;
  • Hepatitis – inflammation of the liver;
  • Increase in the level of transaminases – increase in liver enzymes;
  • Stomatitis – inflammation of the oral mucosa;
  • Peptic ulcer – wound in the mucosa of the esophagus, stomach or small intestine;
  • Asthma;
  • Tinnitus – ringing in the ear;
  • Blurry vision;
  • Paresthesia – tingling in some part of the body;
  • Hemorrhagic anemia.

Read more: Edema: what it is, types and treatments

Price and where to buy?

The price of Ketoprofen may vary according to the geographic region, presentation and brand indicated on the prescription. Among the options, there may be new, generic, similar or interchangeable drugs.

It is also worth mentioning that if there is a need to compare prices, it is possible to use the Consulta Remédios website , which indicates the best drug prices in pharmacies in each region.

Among the options available for Ketoprofen are:


Drugs classified as new can be either drugs that are entering the market for the first time or those that have changed after their launch, be it in the pharmaceutical form or formulation, for example.

Among the new ketoprofen medications are *:

  • Profenid Gel – R $ 20.09;
  • Bi-Profenid, tablets – R $ 33.16;
  • Profenid Retard, delayed – release tablets – R $ 34;
  • Profenid Enteric, delayed – release coated tablets – R $ 40.99;
  • Profenid, hard gelatin capsules – R $ 33.99;
  • Artrosil, prolonged – release hard gelatin capsules – R $ 34.49;
  • Profenid 100mg, box with 10 suppositories for rectal use – R $ 25.29;
  • Profenid, syrup – R $ 16.19;
  • Profenid, solution for oral use – R $ 22.29;
  • Profenid, solution for intramuscular use – R $ 20.09.

* Prices consulted in July 2020. Prices may change.

Read more: What are Suppositories?


Generic drugs are those that have the same active ingredient, dose, pharmaceutical form, indication and route of administration as the reference, but without the commercial nomenclature.

Thus, it is marketed by the name of the active ingredient.

Among Ketoprofen’s generic options and their values ​​* are:

  • Ketoprofen Gel Teuto – R $ 5.56;
  • Ketoprofen EMS hard gelatin capsules – R $ 7.75;
  • Ketoprofen Tablet Medley coated tablets – R $ 8.90;
  • Ketoprofen Germed Pharma prolonged – release tablets – R $ 15.88;
  • Eurofarma ketoprofen solution for oral use – R $ 2.20;
  • Ketoprofen Cristália solution for intramuscular use – R $ 16.94.

* Prices consulted in July 2020. Prices may change.


Similar are the drugs that have the same efficacy and effect as the reference, however, they may have, for example, different excipients, expiration date, labeling and product size.

Some of the available options for similar are *:

  • Bicerto, prolonged – release tablets – R $ 23.90;
  • Ceprofen, hard gelatin capsules – R $ 30.38;
  • Cetofenid solution for oral use – R $ 5.58.

* Prices consulted in July 2020. Prices may change.

Similar interchangeable

Interchangeable similars are those that, as well as conventional similars, have proven efficacy and effect similar to the reference drug.

The difference is that these products can replace, at the time of purchase, the reference drugs prescribed in the medical prescription.

Among the interchangeable similars are *:

  • Algie, prolonged – release coated tablets – R $ 28.20;
  • Artrinid, hard capsules – R $ 8.90.

* Prices consulted in July 2020. Prices may change.

Need a recipe?

-Yeah . For the purchase of medicines containing Ketoprofen as an active ingredient, it is necessary to present a simple white medical prescription.

This means that the sale can only be made to patients who have a medical indication for using the medication.