Profenid: what is it for? Meet the presentations

Inflammatory processes are the body’s response to injury, which can be caused by various causes such as trauma or infections.

When inflammation is formed, it can cause symptoms such as fever , local redness, pain, swelling and, in orthopedic cases, even difficulty in moving a limb.

To treat these manifestations, there are anti-inflammatory drugs, which in addition to alleviating inflammation, usually have analgesic and antipyretic action.

Among the available options is Profenid, a drug used, among others, to treat rheumatic, dental and even urological problems.

Keep reading and learn more about the medication!

What is Profenid?

Profenid is one of the trade names for the active ingredient Ketoprofen, a non-hormonal medication used to treat inflammation and pain caused by otorhinolaryngological, gynecological, urological, dental, rheumatic, orthopedic injuries and various pain processes.

It has anti-inflammatory, analgesic and antipyretic action and its administration forms are: oral (in tablets, capsules, oral solution or syrup), topical (gel), rectal ( suppository ) and intravenous and intramuscular (injection).

The use of the drug is predominantly indicated for adults, with only the oral solution and syrup version recommended for pediatric use.

Is it a medication for child use?

It depends on the presentation. In general, most versions of Profenid have no proven safety and efficacy for use in children. Only syrup and oral solution are indicated for pediatric use.

In the syrup version , the drug is recommended for children older than 6 months. The oral solution is recommended for administration from 1 year of age.

What is the medicine Profenid for?

Profenid is used to relieve inflammation and pain caused by problems that affect different regions of the body, such as rheumatic processes (diseases that affect muscles, joints and skeletons), traumatisms (internal or external injuries) and pain in the body in general. More specifically, it is indicated for:

Otorhinolaryngological processes

Profenid is indicated for some problems related to otorhinolaryngology, that is, that affect the nose, mouth and ears. Among them are:

  • Sinusitis – inflammation of the mucous membranes of the face;
  • Otitis – inflammation of the ear;
  • Pharyngitis – inflammation of the pharynx;
  • Laryngitis – inflammation of the larynx;
  • Tonsillitis – inflammation of the tonsils.

Read more: Pharyngitis: symptoms, remedies and treatments

Gynecological-obstetric processes

Some gynecological-obstetric processes, that is, related to the female reproductive system, can be treated with medication. Among them are:

  • Anexitis – inflammation of the fallopian tubes;
  • Parametritis – inflammation of the tissue that surrounds the uterus;
  • Endometritis – inflammation of the endometrium;
  • Dysmenorrhea – cramps and pelvic pains before or during the menstrual period.

Urological processes

In the case of some problems related to the male reproductive system, Profenid can be indicated as a treatment. Usage recommendations are for:

  • Nephretic colic – pain caused by calculus in the urinary tract;
  • Orchiepididymitis – inflammation of the testicles and epididymis;
  • Prostatitis – swelling in the prostate.

Dental processes

The oral region can be affected by several diseases and, in some cases, medication can be used.

According to the package leaflet, the problems that can be treated with the drug are:

  • Periodontitis – infection of the gum;
  • Pulpitis – inflammation of the dental pulp (the deepest part of the teeth);
  • Abscesses – pouch of pus that accumulates in the tissues of the body;
  • Dental extractions.

Rheumatic processes

Rheumatic processes, that is, that affect muscles, joints and skeletons can be treated with Profenid. Among the indications are:

  • Rheumatoid arthritis – inflammatory disease that affects the joints;
  • Ankylosing spondylitis – type of arthritis that affects the spine and large joints;
  • Gout – inflammation in the joints caused by the accumulation of uric acid in the blood;
  • Chondrocalcinosis – disease caused by the deposit of calcium pyrophosphate inside the joints;
  • Psoriatic rheumatism – type of arthritis that affects people suffering from psoriasis skin disease;
  • Reiter’s syndrome – pain and swelling in the joints caused by inflammation in other parts of the body;
  • Pseudoarthritis – type of arthritis caused by the deposition of calcium pyrophosphate crystals in the joints;
  • Systemic lupus erythematosus – chronic inflammatory disease of autoimmune origin;
  • Scleroderma – chronic inflammatory disease that causes the connective tissues to stiffen;
  • Periarteritis nodosa – inflammation of medium-sized arteries;
  • Osteoarthritis – type of arthritis that causes cartilage wear;
  • Scapulohumeral periarthritis – limitation of shoulder movements and pain at the site;
  • Bursitis – inflammation of the bursae (fluid pouch that protects the joints);
  • Capsulitis – pain and stiffness in the shoulder joint;
  • Synovitis – inflammation of the tissue that internally surrounds the joints;
  • Tenosynovitis – inflammation of the tendon and the tissue covering it (sheath);
  • Tendonitis – inflammation of the tendon;
  • Epicondylitis – irritation of the tissue that connects the muscle of the forearm to the elbow.

Orthopedic injuries

The drug can be used in the case of pain and inflammation caused by injuries to the locomotor system, that is, in regions of the body responsible for locomotion. Among the problems addressed are:

  • Bruises and crushing;
  • Fractures;
  • Sprains – stretching or tearing of the ligaments;
  • Dislocations – dislocation of a joint.

General pains

Among the indications of Profenid, is the relief of general pains of the body, from different origins. Some of the medication indications are:

  • Cervicobraquial neuralgia – pain originating in the nerves of the neck, which radiates to the fingers;
  • Cervicalgia – pain in the neck and shoulder;
  • Low back pain – pain in the lower lumbar region;
  • Sciatica – inflammation or irritation of the nerve roots that lead to the sciatic nerve;
  • Migraine – headache that may be accompanied by nausea, sensitivity to light and blurred vision.
  • Several postoperative.

What is Profenid’s action?

The active ingredient of Profenid, Ketoprofen, is a non-steroidal anti-inflammatory drug (NSAID) – there are no steroidal hormonal components in the composition – that is, it acts by inhibiting the production of substances related to inflammation and pain.

By taking effect, the drug inhibits the synthesis of Prostaglandin, a hormone related to inflammation in the body. When this compound is inhibited, inflammatory effects on the body are alleviated.

Profenid also acts by inhibiting platelet aggregation – a mechanism for attaching platelets to each other -, in addition to having analgesic and antipyretic activity.

Despite this, the package insert indicates that the drug’s mechanism of action is not yet fully understood.

What is Profenid Protect?

Profenid Protect is a medicine that has in its formula the active principle of the conventional Profenid – Ketoprofen -, together with Omeprazole.

It is indicated for the treatment of rheumatoid arthritis (chronic inflammation of the joints) and osteoarthritis (disease caused by wear and tear of the joints) in patients who are at risk of developing ulcers or injuries in the digestive system, when using non-steroidal anti-inflammatory drugs, such as Ketoprofen.

This is because one of the possible side effects of this active ingredient is the attack on the stomach, duodenum or intestine.

The stomach has a substance on its inner wall, such as a gel, that protects the organ from contact with the digestive gastric juice, which is very acidic. This protection is provided by the hormone Prostaglandina, which has the function of regulating stomach acid levels and stimulating the formation of the protective substance.

Non-steroidal anti-inflammatory drugs generally inhibit the production of this hormone, leaving the stomach wall vulnerable to the action of acid, which causes lesions in the region.

Therefore, for patients who are more sensitive to these injuries, but who still need to use Ketoprofen, there is Profenid Protect, a variation that contains Omeprazole in its composition.

Omeprazole is a substance that works by reducing the amount of acid produced by the stomach and treating problems such as gastric ulcers.

Thus, while Ketoprofen works, Omeprazole works by regulating gastric acid so that there is no damage to the digestive system.

What is the difference between Profenid, Profenid Retard, Profenid Enteric, Profenid IV and Bi-Profenid?

Both Profenid and its variations are drugs that have the same indications and active ingredient: Ketoprofen. The difference between them is in the dosage, structure and presentation of the medication.


Profenid is presented in capsules and has a concentration of 50mg. Its structure is simple, with a hard gelatinous coating.

Absorption is rapid and, upon contact with liquid, the capsule expands, releasing the contents present inside.

Profenid Retard

The Retard version has a concentration of 200mg for each tablet and gets its name because it has the characteristic of slow release (called delayed release).

This means that absorption occurs slowly in the body, increasing the period for re-administration.

Thus, if a patient needed to use Profenid 100mg, twice a day, there is, in general, the possibility of replacing with 1 tablet of the Retard version.

In addition, its structure is differentiated, with gastro-resistant coating, that is, it avoids aggressions to the stomach mucosa.

Enteric Profenid

Enteric Profenid is one of the tablet’s options and has 100mg of concentration.

Its release is delayed, that is, released slowly in the body. In addition, it receives such nomenclature because its coating is enteric.

This means that the pill is coated with a substance made so that it passes through the stomach intact, being dissolved only in the small intestine.

This type of action decreases the chances of damage to the stomach, since the medication does not come into direct contact with the mucosa.

Profenid IV

The presentation that is called Profenid IV is that of lyophilic powder and has a concentration of 100mg.

It consists of a powder, which must be diluted and applied directly intravenously, that is, into the vein.

Because it is released directly into the bloodstream, its action is fast, being completely absorbed in approximately 5 minutes.

Profenid IM

Profenid IM is the intramuscular solution for injection, performed only by healthcare professionals and in an appropriate environment.

The dose is 1 ampoule, 2 or 3 times a day, or according to medical advice


Bi-Profenid has a concentration of 150mg of Ketoprofen in each tablet and its release is prolonged.

Thus, the absorption of the drug occurs gradually, being released gradually to the body.

In addition, its structure is double, that is, a two-layer tablet. Each of the ranges contains 75mg of active ingredient, totaling 150mg.

What presentations and milligrams are available?

Milligrams are the available concentrations of a drug. The values ​​generally vary according to the presentation.

In the case of Profenid, there are different versions, which can be used orally, topically or even intramuscularly and intravenously.

The characteristics of each available option are:


One of Profenid’s oral administrations is through capsules. They have a hard gelatinous texture, and each contains 50mg of Ketoprofen.

In general, the package comes with 24 capsules of the drug.


There are three tablet versions of the medication: Profenid Retard, Profenid Enteric and Bi-Profenid. All medicines have the same compound and what differentiates them is the dosage and the coating.

The Profenid Enteric has less milligrams, being 100mg for each tablet. Its coating is simple, that is, 1 layer.

Already Profenid Retard has miligramagem 200mg each tablet. In addition, its release is delayed, that is, the release of medication in the body occurs after a certain time, not immediately after ingestion. Its coating is simple, with only 1 layer.

The Bi-Profenid has miligramagem 150mg of the active ingredient per tablet. Its release is prolonged, that is, the release of the medication in the body is done gradually, over an extended period of time.

In addition, its coating is double, that is, two layers. Thus, each layer contains 75g of Ketoprofen, totaling 150mg.

Rectal suppository

One of Profenid’s available forms of administration is rectal use. The package comes with 10 suppositories.

Regarding milligrams, each suppository contains 100mg of Ketoprofen, the active ingredient of the medication.

Oral solution

The oral solution, that is, the version in drops of Profenid, is one of the presentations of the medicine.

Its milligram is 20mg / mL, that is, for each 1mL of oral solution, there is 20mg of Ketoprofen.

In addition, it is important to note that 20 drops total 1mL of oral solution. Thus:

  • 1mL = 20 drops = 20mg of Ketoprofen.


The syrup presentation, that is, oral use, is for pediatric administration (over 6 months).

According to the package insert, the available milligram is 1mg / mL, in a bottle of usually 150mL.

Intramuscular Injection

1 ampoule should be administered intramuscularly, 2 or 3 times a day, at medical discretion. The maximum recommended daily dose is 300 mg.


The gel is the topical version of Profenid. Along with the package, accompanies 1 tube of 30g.

The concentration of the product is 25mg / g, that is, for every 1 gram of gel, there is 25mg of Ketoprofen.

Solution for injection

The solution for injection is for intramuscular use. The package is accompanied by 6 ampoules containing 2mL of product each.

The drug concentration is 50mg / mL, that is, for each 1mL of product, there is 50mg of active ingredient.

As the ampoule contains 2mL of the medication, there are 100mg of Ketoprofen in each one.

Injectable lyophilic powder

The lyophilic powder (Profenid IV) is for intravenous use, that is, applied directly to the vein. In the package, there are 50 vials containing the medication.

According to the package insert, the drug concentration is 100mg. Thus, each vial has 100mg of Ketoprofen.

Which is better Ibuprofen or Profenid?

Both Ibuprofen and Profenid are drugs that have the treatment of rheumatic processes as an indication, in addition to having analgesic and antipyretic action. Both have a similar mechanism of action, which works by inhibiting the synthesis of prostaglandins, a hormone related to inflammation.

In general, there is no way to determine the best drug, since the indication may vary according to the patient’s clinical condition and health history. Thus, a drug that is effective for one person, may not be as interesting for another.

Thus, it is always worth seeking medical advice, which will indicate the best medicine for each situation.

How long does it take to make the Profenid effect?

It depends. The time taken for Profenid to take effect may vary according to the presentation used by the patient. In general, the maximum absorption time, that is, the period that the drug takes to be absorbed by the body, for each version is:

  • Capsule – 60 to 90 minutes;
  • Tablet – 60 to 90 minutes;
  • Bi-Profenid – 15 to 30 minutes;
  • Lyophilic powder – 5 minutes;
  • Solution for injection – 20 to 30 minutes;
  • Oral solution – 60 to 90 minutes;
  • Suppository – 45 to 60 minutes;
  • Syrup – 30 minutes.

Despite this, it is worth mentioning that not all symptoms will necessarily disappear soon after the effects of the medication start.

In general, the medication will start to act during this period, however, the improvement of symptoms depends on other factors, such as the intensity of the clinical condition and the response of the patient’s organism to the medication.

Dosage: how to use according to the package leaflet?

The use of Profenid may vary according to the presentation: capsule, tablet, suppository, oral solution, syrup, gel, solution for injection or lyophilic powder.

Specifically, the form of administration of each variety is, according to the package leaflet:


The capsule version is recommended to take 2 capsules, 2 times a day or 1 capsule, 3 times a day .

It is recommended to use the medicine during or after meals, together with a glass of water.

The maximum daily dose described on the package insert is 300mg.


The use of Profenid in tablets may vary according to the two types of medication: delayed-release and prolonged-release.

According to the package insert, the indication for use for each one is:

Delayed release (Profenid Retard)

In the delayed release version, it is recommended to make use of:

  •  1 tablet, morning or evening.

It is worth mentioning that only 1 tablet should be administered per day.

Prolonged release (Bi-Profenid)

The prolonged-release tablet is Bi-Profenid, that is, it has a higher dosage.

According to the package insert, there are two ways to administer the medication, one for the specific treatment of migraine and the other for general problems.

For use in general cases , administration should be done in two stages: attack dose and maintenance dose.

The attack dose is one in which there is the objective of quickly reaching a certain concentration of medication in the body, so that the body can tolerate the application of other doses afterwards (maintenance).

For general cases , the indication of use is:

  • Attack dose: 2 tablets per day, divided into 2 applications;
  • Maintenance dose: 1 tablet, 1 time a day.

For the specific treatment of migraine , the recommendation is to take ½ tablet of Profenid soon after the onset of the crisis .

It is worth mentioning that there must be an interval of at least 12 hours between the administration of one dose and another.

Thus, even if the symptoms are not relieved with the dose ingested, administration of a new dose is contraindicated before 12 hours of the last ingestion.

Rectal suppository

The indication for using the rectal suppository is 1 application, 2 times a day , once in the morning and once in the evening.

To carry out the application, some steps must be followed:

  1. Perform hand hygiene with soap and water;
  2. With your thumb and index finger, move your buttocks apart;
  3. Insert the suppository into the anal cavity;
  4. Gently press one buttock against the other, to prevent the medication from coming back.

On hot days, according to the package insert, it is recommended to put the medicine in cold water or refrigerator for a few minutes before removing it from the packaging, to prevent it from softening.

Oral solution

The version in oral solution, that is, in drops, must be diluted together with a little water for administration.

The use for children is:

  • Above 1 year: 1 drop per kg of weight every 6 or 8 hours;
  • From 7 to 11 years: 25 drops, every 6 or 8 hours.

As for application in adults , the indicated is:

  • 50 drops every 6 or 8 hours.


The package insert indicates that the use of Profenid in syrup should be done with the dosage:

  • 0.5mg / kg / dose , 3 to 4 times a day .

It is worth mentioning that it is necessary to have an interval of 4 hours between each application. In general, the treatment period varies between 2 to 5 days.


For the administration of the gel, just apply the product under the inflamed or painful place, 2 to 3 times a day , and massage for a few minutes.

The amount of product may be adequate to cover the entire area of ​​the affected area, however, the daily dose should not be greater than 15g.

In addition, according to the package leaflet, treatment with the drug should not extend more than 1 week.

Solution for injection

Profenid’s solution for injection is applied intramuscularly, that is, inside the muscle. It must be administered by a health professional and, according to the package insert, the recommended dosage is 1 ampoule , 2 to 3 times a day .

The injection should be done in the upper quadrant of the buttock, slowly and deeply. Before applying, it is worth aspirating the syringe to confirm that the needle is not in a blood vessel.

Lyophilic powder

The administration of the lyophilic powder version is done exclusively intravenously, that is, in the vein, and must be applied by a trained health professional.

The indicated preparation, which must be done immediately before use, is:

  1. Dilute the contents of the flask in 100 to 150mL of isotonic solution of glucose or sodium chloride;
  2. Administer via slow infusion for approximately 20 minutes .

For cases of renal colic, treatment should be done for a maximum of 48 hours.

Can you give Dipirona and Profenid?

In general, yes . According to the package insert, there is no relevant drug interaction between the drugs Dipirona and Profenid.

Dipyrone is a medication that has antipyretic and analgesic effects, and can be used in several pathologies that cause symptoms of fever and pain. Profenid is an anti-inflammatory medication.

In some cases, with medical guidance, they can be administered together.

What are the side effects of Profenid?

Profenid can cause side effects in some people, causing disorders in the digestive system, vision, liver, skin, among others. Common reactions such as nausea, vomiting, diarrhea and headaches can also occur.

Common side effects caused by medication include:

  • Dyspepsia – indigestion;
  • Nausea;
  • Abdominal pain;
  • Vomiting.

Among the unusual reactions , which may occur, are:

  • Headache – headache;
  • Vertigo – dizziness;
  • Somnolence;
  • Constipation – constipation;
  • Diarrhea;
  • Flatulence – gases;
  • Gastritis;
  • Rash;
  • Itching – itching;
  • Edema – swelling.

Read more: Edema: what it is, types and symptoms

Rare reactions are:

  • Weight gain;
  • Hepatitis – inflammation of the liver;
  • Increase in the level of transaminases – increase in liver enzymes;
  • Stomatitis – inflammation of the oral mucosa;
  • Peptic ulcer – wound in the mucosa of the esophagus, stomach or small intestine;
  • Asthma;
  • Tinnitus – ringing in the ear;
  • Blurry vision;
  • Paresthesia – tingling in some part of the body;
  • Hemorrhagic anemia.

It is worth remembering that each organism reacts differently to the medication. Thus, not all patients will necessarily suffer from the reactions.

Are you generic?

-Yeah . There is a generic version of the drug Profenid.

Generic drugs are those that have the same active ingredient, dose, pharmaceutical form, indication and route of administration as the reference, but without the commercial nomenclature.

Thus, it is marketed by the name of the active ingredient, in this case, Ketoprofen.

Some generic options for Profenid are:

  • Ketoprofen Tablet Medley ;
  • Ketoprofen EMS ;
  • Ketoprofen Gel Teuto ;
  • Ketoprofen Drops Medley .

Price: what is the average price and where to buy?

The price of Profenid may vary according to the geographic region, establishment of purchase and presentation indicated.

On average, the initial * values ​​are:

  • Profenid Retard – R $ 36.69;
  • Enteric Profenid – R $ 44.19;
  • Profenid Gotas – R $ 25.85;
  • Profenid Protect – R $ 41.35;
  • Bi-Profenid – R $ 31.25;
  • Profenid Capsule – R $ 32.50;
  • Profenid Syrup – R $ 17.39;
  • Suppository Profenid – R $ 26.05;
  • Profenid Gel – R $ 20.42;
  • Injectable Profenid – R $ 4.02.

If there is a need to compare prices and make a purchase, it is possible to use the platform of Consulta Remédios , which indicates the best prices for medicines in different pharmacies in each region.

* Prices consulted in June 2020. Prices may change.

Some health problems can cause major discomfort such as pain and swelling. To alleviate this type of discomfort, there are different medications that can be used and, among them, Profenid.

People who suffer from rheumatic processes, oral infections and even migraine pain may find the drug a good option for symptom relief.

Want to know more about medicines and treatments? The Healthy Minute has other complete content for you! Read more and stay informed!