Menopur: how does the treatment for infertility work? Fat?

The desire to have a baby is common to many people. Unfortunately, not all of them are able to get pregnant easily and need a “push” from medicine.

The good news is that drugs with Menopur can be used in such cases.

Do you want to know more about this remedy? Then follow the text:

What is Menopur?

Menopur is a biological medication that is indicated for the treatment of infertility. The application is made by injection via intramuscular or subcutaneous. The 75UI version can be used on men and women while the 600UI or 1200UI version can only be applied on women.

The active ingredient in this medication is Menotropin, an association of follicle stimulating hormones (FSH) and luteinizing hormone (LH) to treat conditions of insufficiency in the production of one or both hormones.

Special populations

Pregnant women, women who are breastfeeding, the elderly, children and patients allergic to Menotropin or other ingredients in the formula should not take Menopur.

This is because this medicine can compromise the health and well-being of these groups.

Lactose intolerants should also be on the lookout for treatment with Menopur, as the formula for this drug contains this type of sugar.

Women with obesity (with a body mass index greater than 30 kg per m²) or known risks of developing thrombosis should be guided by a medical professional to assess the benefits and risks of taking Menopur.

What is the medicine Menopur for?

Menopur is indicated to treat female and, in some cases, male infertility. That is, it is used by people who wish to conceive. In women, it stimulates the growth of follicles, inducing ovulation. In men, the action is a stimulus in the testicles to produce more sperm.

How does the active ingredient Menotropin work?

Currently, Menotropin is the active ingredient of 3 drugs used for the same function: Menopur, Merional and Menogon.

This substance is a combination of hormones called LH (luteinizing hormone) and FSH (follicle-stimulating hormone), which stimulate the growth of ovarian follicles.

But why does it help to get pregnant?

The follicle is made up of epithelial cells. When it grows and reaches its maturation, it becomes an egg that is released (ovulation).

In a simpler way: Menotropin is a set of hormones that promotes the correct development of the egg and contributes to ovulation induction.

In men, on the other hand, the way of acting is similar. The main difference is the action of the drug is in the testicles, which are stimulated to produce sperm.

This substance is mainly eliminated by urine.

How is Menopur applied?

If you have any doubts as to the correct way to give the injection, read the package leaflet or seek guidance from a health professional. The Menopur bulbar recommends that the first subcutaneous application be made under the supervision of a doctor, following the steps below:

  1. Wash your hands well and use a smooth and clean surface as a support;
  2. Open the package and place the needle in the syringe (be careful not to break or bend the needle);
  3. Reserve the empty needle;
  4. Take the ampoule with the reagent liquid and place your thumb on the blue dot;
  5. Press that part of the ampoule against you until it breaks (as if pushing the bottle). If you want, you can use gauze to avoid cutting yourself;
  6. Take the syringe and place the needle inside the ampoule;
  7. Pull the syringe barrel upwards, sucking all the liquid;
  8.  Open the bottle with the powdered medicine;
  9. Place the syringe inside this bottle with the powdered medicine and place the liquid present on the needle (do this slowly to avoid the formation of bubbles);
  10. Gently stir the bottle so that the powder and liquid mix more quickly;
  11. Wait for 2 minutes until the solution is homogeneous and clear;
  12. Suck that solution again with the syringe;
  13. Turn the needle upwards and press the cannon until only the 1st droplet of the medicine comes out (this is important to completely eliminate air bubbles);
  14. Use a piece of cotton wool with alcohol to disinfect the area where the injection will be given;
  15. Form a fold with your skin with your non-dominant hand;
  16. With your dominant hand, insert the needle into this fold. Do this quickly and keep the syringe at 90º from the rest of the body;
  17. Squeeze the syringe barrel so that the medication is released;
  18. When the syringe is empty, remove it gently;
  19. Gauze or cotton can be used under the application site to stop any bleeding;
  20. If necessary, apply a bandage over the site.

The health professional who is guiding you will indicate which are the best places to give the injection (usually, thighs, arms and belly are the most common);

Remember that this garbage must not be disposed of with common waste. There are syringe collection points in hospitals and pharmacies.

What is the recommended dosage?

The dosage indicated is variable for each case. That’s because the amount of hormones and responses to treatment are different for each organism.

Therefore, the ideal is to follow medical recommendations. This professional is also able to make possible changes in the amount of Menopur that should be applied, if necessary.

During the entire period of use of Menopur, blood or ultrasound tests should be done frequently to monitor the hormonal amount in the body.

The gender of the patient will also influence the dosage of this medicine as well as the combination with other methods and treatments:

Men

Initially, men should receive between 1,000 IU and 3,000 IU of testosterone. Only after reaching this condition, should you administer between 75UI and 150UI of Menopur, 3 times a week for a few months.

Women

Treatment is usually started within the first 7 days of the menstrual cycle. In this phase, the daily dose varies between 75 IU and 150 IU.

If the doctor believes that the initial dose is being insufficient, it is possible to adjust this amount as long as the maximum limit of Menopur applied is 225 IU per day.

If 4 weeks (20 days) of treatment have passed with the maximum dose and the results of the blood tests show that the medicine is not having the expected effect, the gynecologist or fertility professional tends to prescribe another medication.

How long does it take for Menopur to take effect?

The ideal is to estimate the time of action with the guidance of a medical professional, as this may vary according to factors such as the use or not of other remedies to stimulate ovulation, the amount of hormones present in the body and gender of the person. Anyway, each case is a different situation.

An important detail that is mentioned in the package insert is that treatment with Menopur increases the probability of a multiple pregnancy (of twins, for example).

It is worth remembering that Menopur is a medication to treat infertility to increase the chance of becoming pregnant.

Although it is rare, there are cases of people who have not managed to conceive despite undergoing treatments to conceive.

The chances of this happening are greater if the woman has a history of:

  • Ectopic pregnancy;
  • Loss of the baby in other pregnancies;
  • Presence of tumors in the ovaries (ovarian neoplasia);
  • Malformation of the baby in previous pregnancies.

What are the side effects of Menopur?

Like all medicines, the use of Menopur can also cause adverse reactions. Among them, the main one is the development of Ovarian Hyperstimulation Syndrome (SHEO), which mainly affects women with polycystic ovaries (PCOS) and causes nausea, vomiting, diarrhea , weight gain and ovarian torsion.

Therefore, patients who already have PCOS or SHEO should talk to the doctor about this history before starting treatment with Menopur, as this medication tends to worsen the conditions of these diseases.

Other side effects can also be caused by the administration of Menopur.

In order to facilitate information, the package insert divides adverse reactions according to the frequency with which they manifest:

Ordinary

Common reactions occur in 1% to 10% of cases:

  • Pain and enlarged abdomen;
  • Motion sickness;
  • Headache;
  • Pain and redness at the injection site;
  • Ovarian Hyperstimulation Syndrome (SHEO).

Unusual

Uncommon classified side effects manifest in 1% to 0.1% of (of) patients:

  • Vomiting;
  • Diarrhea;
  • Tiredness;
  • Dizziness;
  • Ovarian cysts;
  • Heat waves (hot flushes);
  • Discomfort in the breasts.

Rare

Adverse reactions considered rare are those that occur in less than 0.1% of people who used the drug.

In the case of Menopur, they are acne , redness and sores on the skin.

Unknown frequency

Side effects with unknown frequency are those that did not manifest themselves sufficiently in laboratory tests for their periodicity to be estimated.

In the case of Menopur, they are:

  • Fever;
  • Malaise;
  • Hypersensitivity;
  • Weight gain;
  • Pain in muscles and bones;
  • Twisting of the ovaries;
  • Itch;
  • Skin irritation and redness (hives);
  • Blood clots in the blood vessels;
  • Visual disorders.

Does Menopur get fat?

Among the possible side effects caused by Menopur is weight gain. Thus, it is possible that this medicine causes some people to put on weight.

However, like other adverse effects, weight gain is a condition that will not necessarily occur. It is also necessary to talk to professionals to receive guidance on the care and habits that should be adopted.

Do you have contraindications?

Yes, Menopur has contraindications for both women and men. Therefore, in case of doubt, seek medical advice.

Menopur is contraindicated for women :

  • Have tumors in the uterus, ovaries, breasts, pituitary or hypothalamus;
  • Are pregnant or breastfeeding;
  • Have vaginal bleeding for no apparent reason;
  • They have enlarged ovaries;
  • Have early menopause;
  • Have malformation of Organs genitals;
  • They were diagnosed with ovarian deficiency.

If the woman has complications in the thyroid, adrenal gland or prolactin (hormone) in the blood , these conditions must be treated before starting treatment with Menopur.

Already the men should not receive this medicine if you have had prostate cancer or testicular tumors .

Value: what is the price of Menopur?

The price of this medicine varies according to the quantity of ampoules that comes in each box and how many IU each one of these bottles contains. The presence or absence of syringes in the packaging also reflects the price.

For example:

An ampoule with 75UI of Menopur powder + an ampoule with 1ml of diluent costs between R $ 103.50 and R $ 143.98 *.

The same dosage, but with 5 ampoules in the package has an average price of R $ 810.65 *.

Since an ampoule of Menopur 600UI powder + one 1mL vial + diluent empty syringes 9 is a variation of R values between $ 882.00 and $ 1048.15 * R.

Prices are even higher for 1 bottle with 1200UI of Menopur powder + 2 ampoules with 1 mL of diluent + 18 empty syringes. This kit can cost from R $ 1,765.00 to R $ 2,071.05 *.

* Prices consulted in March 2020. Prices may change.   

Is Menopur Generic?

Menopur is a drug that does not have generics or similar , as it is a biological substance.

However, the active ingredient Menotropin is also marketed by two other brands, Menogon and Merional .

Menogon is manufactured by the same company as Menopur, Ferring. Merional is handled by the pharmaceutical company Meizler UCB.

Does Menopur have it in SUS?

No. The Unified Health System (SUS) does not offer Menopur or other menotropin-based medications.

However, it is possible that there is still a judicial attempt to obtain the cost of the medication by the State or, if the client is a health insurance plan, by the contracted company.

In cases of doubt, the most correct is to seek the advice of a lawyer.

Is it approved by ANVISA?

Yes. The National Health Surveillance Agency (ANVISA) approves the manipulation and trade in Menopur.

The Swiss pharmaceutical company Ferring has been authorized since March 2002, being able to commercialize this medicine until the registration expires in March 2027.

How to budget Menopur?

Making a budget is sometimes not an easy task.

To make your life easier, Consulta Remédios developed an advisory program for high-cost drugs.

It’s very simple. Just access the link , fill the form with your personal data and over time, our team will send you a complete and personalized quote with at least 3 pharmacies that provide this remedy.


Menopur is a remedy indicated for the treatment of infertility. Its application is complex and must be guided by a health professional.

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