Is Dipyrone good for headaches? See directions for use

The dipyrone is an analgesic indicated for headaches, fever and muscle pain.

The first effects of this drug begin to appear between 30 minutes and 1 hour after ingestion, and may last for an average of 4 hours.

Although it is quite common, there are no difficulties in finding it in pharmacies, there are some contraindications and precautions when taking it.

For example, pregnant women, lactating women, people with asthma and liver problems , as well as babies under 3 months old or weighing less than 5kG are contraindicated to use.

There being no conditions that affect the absorption of the drug, Dipyrone acts quickly, relieving pain, and can be stopped at any time without causing complications and chemical dependence.

If in doubt, contact a health professional such as a doctor, nurse or pharmacist.

Read more: Can pregnant women take dipyrone? Does it harm the baby?

Is Dipyrone good for headache and fever?

In general, yes. Dipyrone, in addition to treating headache , can be taken to relieve fever, as long as it is mild or moderate. Therefore, it is also considered an antipyretic.

This type of medicine prevents the production of prostaglandin. When produced in excess, this substance, which is a mediator of inflammation, affects the hypothalamus (region of the brain responsible for controlling body temperature).

In addition, prostaglandin is also related to pain. Therefore, when taking dipyrone, an analgesic effect occurs due to the reduction of the substance.

However, very severe headaches or a high fever (above 38.5 ° C) may not be fought by dipyrone, as dipyrone alone is not enough to fight prostaglandin production.

It is also important to note that dipyrone fights only fever and not the cause of this rise in temperature (in some cases, fever is a symptom of infections or inflammations).

Is Dipyrone good for a hangover headache?

In the vast majority of cases, yes.  Dipyrone is a pain reliever that works on all types of headaches, no matter the cause of this discomfort.

In the case of a hangover, the effect of the medication is faster and more effective if it is accompanied by rest and a lot of water intake.

Another tip that helps in this situation is to take care of the food. Avoid consuming very heavy foods, other doses of alcohol or medications that can be aggressive to the stomach.

Do not take medication before or shortly after consuming alcoholic beverages. 

When you do this, the effect of the medication can be canceled (in the mildest cases) or accentuated, causing dizziness, vomiting and even fainting (in the most severe cases).

Read more: Moderate alcohol consumption is also bad for your health

Dipyrone sodium or monohydrate: how to buy? How to take?

Both sodium dipyrone and dipyrone monohydrate are the same in terms of product content. The only difference is the packaging label, which was changed by a determination of the National Health Surveillance Agency (ANVISA).

As the nomenclature change is in transition, soon, all packaging will appear as dipyrone monohydrate.

Dipyrone can be purchased at pharmacies or portals such as Consulta Remédios . The drug is available in tablets, drops, suppository and in an injectable form.

The value varies between R $ 1.50 and R $ 25.00 depending on the brand, the way it is presented and the region where the pharmacy is located.


Dipyrone drops are recommended mainly for children, because the drug can be swallowed more easily.

The number of drops that must be administered depends on the child’s weight, ranging from 2 drops (for babies with 5kG) to 35 drops (for children with 53kG).

The dipyrone in drops can be taken every 6 hours. The maximum limit is 4 doses per day.

Some adults also prefer to take medications in gout . In this case, if the person weighs more than 53 kg, he must take 40 drops every 6 hours, as long as he does not exceed 4 doses per day.

If you miss the dose of dipyrone in drops, take it as soon as you remember.

However, if the time for the next dose is close, wait until this time to use the drug.

Do not double the amount of drops to make up for the missed dose.


The dipyrone tablet can only be ingested by those over 15 years of age. Babies and younger children should take the drop version.

The medicine can be taken every 6 hours, as long as it does not exceed the limit of 4 tablets of 1g per day or up to 8 capsules of 500mg, which can be taken fasting or not.


Suppository dipyrone can be used by children over 4 years old or weighing more than 16kG.

The remedy can be applied every 6 hours with a maximum of 4 doses per day. Dipyrone when presented as a suppository should be used anally, in order to lower fever or reduce pain in patients who have difficulty swallowing tablets or liquids.

To use the suppository, follow these steps:

  1. Wash and sanitize your hands before the process;
  2. Find a comfortable position (lying or standing);
  3. Spread the buttocks and gently insert the entire suppository into the anal orifice;
  4. Compress, for a few seconds, one buttock with the other to prevent the suppository from returning.


This dipyrone presentation can be applied to people of all ages (as long as above 5kG), varying the dosage according to weight.

For example, in children, it should be applied between 0.1mL of the medicine (in babies with 5kG) to 1.8mL (in children with 53kG).

For infants under 1 year, the injection is mandatory intramuscular. Above that age, it can also be applied intravenously.

Adults over 53 kg should receive between 2mL and 5mL of dipyrone, being able to receive up to 10mL per day.

Emphasizing that the injectable administration must be performed by duly qualified health professionals, according to the instructions on the package insert, respecting the patient’s weight and age.

Adverse reactions: what is the effect of dipyrone?

Adverse reactions are effects already observed after administration of the drug, but do not necessarily mean that they will happen. Depending on the package insert, these effects can vary from common situations to more rare occurrences.

Immune system changes

Disorders of the immune system, such as anaphylactic shock, manifesting from itchiness, burning or redness in the skin or mucous membranes, shortness of breath, cardiac arrhythmias, pressure drop and generalized itching are also possible.

Blood disorders

As for disorders of the blood and lymphatic system, agranulocytosis (reduction of a type of white blood cells) and pancytopenia (reduction of red and white blood cells, in addition to platelets), leukopenia (reduction of white blood cells) and thrombocytopenia (decrease of platelets) can occur .

Kidney problems

People who already have diseases or predisposition to kidney problems should avoid consumption without medical advice.

Anyone who already suffers from some condition of kidney dysfunction may have the condition aggravated. There is also a reduction in the production of urine or increased elimination of proteins in the urine.

Non-digestive system problems

Some patients reported the presence of blood in the stool accompanied by stomach pain after taking dipyrone.

Wounds in the digestive system can also occur, mainly along the intestines and stomach resulting from the indiscriminate use of the medication.

Heart and pressure problems

The patient may have cardiac disorders, such as Kounis syndrome, in which there is an obstruction of the coronary artery (acute coronary event) and allergic reactions affect the patient together.

Although in rare cases, situations such as palpitations (which increase or decrease the heart rate), severe chest pain and heart attack have also been reported after taking the drug.

Skin problems

Although it is in rare cases, dipyrone can cause small rashes or sores on the skin on all parts of the body.

If this is the case, discontinue use and see a dermatologist to properly treat these skin disorders.


Dipyrone, regardless of how it is presented, can cause drowsiness when consumed at high dosages. However, for the recommended doses, no effect

adverse effect on the ability to concentrate and react is reported in the package insert.

After taking dipyrone, try to rest if possible. The body recovers better and faster during rest.

How to use: how many dipyrone tablets can I take at one time?

It depends on the dosage of the pill – 1g or 500mg. A second can be taken after 6 hours, with the maximum limit of 4 tablets of 1g per day (for dosages of 500mg, the orientation is 1 to 2 tablets up to 4 times a day).

If there is an overdose of dipyrone, the person should be taken to a hospital urgently.

The other presentations of dipyrone (in drops, oral or injectable solution) should also be administered preferably in single doses. If there is no improvement in symptoms, it is necessary to seek medical advice, investigating the source of the pain or fever.

If in doubt, seek medical advice.

Dipyrone is indicated to treat headaches and fever. This drug can be found in drops, tablets, injectable, syrup or suppository. But avoid self-medication . Consult a doctor or a pharmacist.

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