Bonar: find out what it is for and the forms of administration

Bonar is a drug indicated for the treatment of carcinomas, lymphomas and cases of pleural effusion .

Its use should always be done with the help of a health professional. In case of doubt, talk to the doctor who prescribed this medicine.


What is Bonar?

Bonar is a similar interchangeable medicine that can be applied in several ways: intramuscular (in the muscle), intravenous (in the vein, as if it were a serum), intrapleural (applied to the back and directly affects the lung) or subcutaneous (below the skin) .

This medication can be used as the only form of treatment or as a complementary therapy with other substances.

Such a drug should not be used by people who have allergic reactions to Bleomycin Sulfate (active ingredient) or any other substance present in the formula.

Bleomycin Sulfate is a combination of several cytotoxic antibiotics (capable of destroying other cells) that are taken from fragments of a bacterium called Streptomyces verticillus. 

Can you have drug interaction?

First of all, it is important to explain that the drug interaction happens when one drug interferes with the action or metabolism of the other.

Bonar can influence the effect of drugs that contain the following substances:

  • Phenytoin ;
  • Ascorbic acid (Vitamin C) ;
  • Carbenicilina;
  • Cefazolina;
  • Hydrocortisone Sodium Succinate ;
  • Sodium penicillin G;
  • Sodium methotrexate;
  • Aminofilina,
  • Cephalothin ;
  • Terbutaline .

This remedy should also not be administered together with solutions that have amino acids, since there may be a risk of precipitation (when the correct dilution of the active ingredient does not occur).

What is the medicine Bonar for?

Some drugs, such as Bonar, are able to treat several diseases, because of their mechanism of action in the body.

In the case of Bonar, this remedy is indicated for the treatment of carcinomas, lymphomas and pleural effusion.

But what are these conditions? Let’s explain each of them:

Squamous cell carcinomas

Carcinoma is a scientific name for tumors composed of malignant cells that reproduce abnormally, popularly known as cancer .

The most common types of carcinomas that Bonar fights are those that manifest:

  • On the head: mouth, tongue, sinuses, skin, palate (roof of the mouth) and gums;
  • In the neck: larynx, pharynx, epiglottis and tonsils;
  • In the reproductive system: vulva, vaginal canal (uterine cervix), penis and testicles.


The lymphatic system is made up of white blood cells which are cells responsible for the defense of the organism against viruses, bacteria and fungi.

But these cells can become malignant and reproduce abnormally, forming tumors called lymphomas.

Such tumors can be of 2 types: Hodgkin’s lymphoma and non-Hodgkin’s lymphoma.

The main difference between these 2 types of tumors is the presence of a cell called the Reed-Sternberg, present in the Hodgkin type.

This cell is malignant and can represent up to 2% of the general mass of the tumor.

Bonar is indicated for palliative treatment of Hodgkin’s lymphoma when the disease is in the IVA and IVB stages (which are more advanced).

It is possible that this medication is indicated as a complement to other forms of treatment (such as radiotherapy).

If the patient has Hodgkin’s lymphoma IA or IIA, which are milder stages of the disease, treatment is done only with radiotherapy.

Pleural effusion

Quite simply, it can be said that pleural effusion is the accumulation of water inside the pleura (membrane that lines the lung).

It is worth saying that the condition itself is not a disease, but a sign of the presence of other diseases (such as lung cancer ).

When Bonar is used to treat this condition, it is applied with an intrapleural injection (that is, the injection will be taken in the back and the needle will reach the lung).

How to use Bonar according to the package leaflet?

The package insert indicates that the use of Bonar should only be done with the help of a medical team and in a hospital environment.

The dosage indicated varies according to the type of condition that the drug is treating:

  • Carcinoma and lymphomas: intravenous, intramuscular or subcutaneous application of 0.25 to 0.50 units per kg (10 to 20 units / m²);
  • Pleural effusion: 60 units that must be administered by intrapleural injection.

Patients with renal failure should have their dosage adjusted due to the increased likelihood of increased bleomycin toxicity.

The amount of creatinine that is released into the blood can also influence the dose of Bonar:

Creatinina (ml / min)% dose
greater than or equal to 50100%
40 a 5070%
30 a 4060%
20 a 3055%
10 a 2045%
5 a 1040%

When was it approved by ANVISA?

Bonar’s first registration with the National Health Surveillance Agency (ANVISA) was carried out in January 1998 by the pharmaceutical company Biosintética. But, in 2004, another pharmaceutical company, Aché bought Biosintética, thus, the authorization to produce the medicine Bonar passed from Biosintética to Aché.

In February 2019, Aché made a new registration of Bonar with ANVISA, as the official holder of the right to sell the medicine. This new authorization is valid until April 2025.

What are the side effects?

Like all medicines, Bonar can also cause some side effects, which are divided on the package leaflet according to how often they occur:

Very common

Very common adverse reactions occur in more than 10% of patients who use the drug:

  • Swelling in the hands and feet;
  • Redness or pallor in the skin;
  • Cracks and calluses on the skin (hyperkeratosis);
  • Darkening of the skin;
  • Hair loss ;
  • Bubbles;
  • Inflammation in the veins (phlebitis);
  • Itch.


When side effects manifest between 1% and 10% of cases, they are classified as common:

  • Pressure fall;
  • Mental confusion;
  • Fever ;
  • Chills;
  • Pneumonia;
  • Pulmonary fibrosis.

No set frequency

Adverse reactions without a defined frequency of Bonar are:

  • Motion sickness;
  • Vomiting;
  • Alteration of taste;
  • Tromboses;
  • Stroke ;
  • Infarction ;
  • Reduction in the number of platelets;
  • Changes in liver and kidney functions;
  • Loss of skin elasticity.

Price: how much does Bonar cost?

The box with 1 powder vial for solution for injection has a minimum value of R $ 255 *.

If you are unable to purchase this medication, you will need to file a lawsuit, as Bonar is not offered by the Unified Health System (SUS).

For that, it will be necessary the assistance of a lawyer, in addition to documentation that includes the medical report that proves the need for the medicine and a budget with at least 3 establishments that sell the drug.

How to budget Bonar?

To make Bonar’s budget, you can count on the Consultancy of Consultations Remedies.

Just access the link and fill out the form with your personal data. Ready! In a short time our team will send you a personalized and exclusive quote for your case.

Bonar is indicated for the treatment of malignant cells (carcinomas and lymphomas) and pleural effusion.

Its form of application is varied and complex and therefore requires the help of a health professional.

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